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Cleaved-COL1A2 (G1102) Polyclonal Antibody

Cleaved-COL1A2 (G1102) Polyclonal Antibody

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Specification

Product name Cleaved-COL1A2 (G1102) Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of human COL1A2 at AA range: 1020-1100
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative COL1A2; Collagen alpha-2(I) chain; Alpha-2 type I collagen

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in COL1A2, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen(COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for COL1A2.
Gene ID 1278
Alternative COL1A2; Collagen alpha-2(I) chain; Alpha-2 type I collagen
Others Cleaved-COL1A2 (G1102) Polyclonal Antibody detects endogenous levels of fragment of activated COL1A2 protein resulting from cleavage adjacent to G1102.
Accession P08123
Observed Band(KD) 92

Image & description

Fig.1. Western Blot analysis of various cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000.

Fig.1. Western Blot analysis of various cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of VEC cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of VEC cells using Cleaved-COL1A2 (G1102) Polyclonal Antibody diluted at 1:1000.

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