| Product name | Cleaved-Cathepsin D LC (G65) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human Cathepsin D LC at AA range: 20-100 |
| Host | Rabbit |
| Reactivity | Human,Monkey |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CTSD; CPSD; Cathepsin D |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 17kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | CTSD encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in CTSD play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. |
| Gene ID | 1509 |
| Alternative | CTSD; CPSD; Cathepsin D |
| Others | Cleaved-Cathepsin D LC (G65) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin D LC protein resulting from cleavage adjacent to G65. |
| Accession | P07339 |
| Observed Band(KD) | 17 |
Fig. Western Blot analysis of various cells using Cleaved-Cathepsin D LC (G65) Polyclonal Antibody.
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