| Product name | Claudin-19 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human Claudin-19 at AA range: 50-130 |
| Host | Rabbit |
| Reactivity | Human,Rat |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CLDN19; Claudin-19 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 23kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | The product of CLDN19 belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in CLDN19 are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for CLDN19. |
| Gene ID | 149461 |
| Alternative | CLDN19; Claudin-19 |
| Others | Claudin-19 Polyclonal Antibody detects endogenous levels of Claudin-19 protein. |
| Accession | Q8N6F1 |
| Observed Band(KD) | 23 |
Fig. Western Blot analysis of various cells using Claudin-19 Polyclonal Antibody diluted at 1:500.
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