| Product name | Claudin-1 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Claudin-1 at AA range: 140-220 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IF, IHC-P, WB |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Alternative | CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 22 KD |
| Storage buffer | PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. |
| Gene ID | 9076 |
| Alternative | CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein |
| Others | Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein. |
| Accession | O95832 |
Fig. Western Blot analysis of various cells using Claudin-1 Polyclonal Antibody diluted at 1:1000.
Author：Li Y, Liu H, Qi H, Tang W, Zhang C, Liu Z, Liu Y, Wei X, Kong Z, Jia S, Du B, Yuan J, Wang C, Li M Publication name：Biomed Pharmacother IF：4.545
Author：Li Y, Liu M, Liu H, Sui X, Liu Y, Wei X, Liu C, Cheng Y, Ye W, Gao B, Wang X, Lu Q, Cheng H, Zhang L, Yuan J, Li M Publication name：Front Cell Infect Microbiol IF：4.123
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1.The species of antibody reactivity should be the sample species that can be matched normally after Abbkine R&D experts have passed strict scientific verification. If your sample is not within the range of reactivity, in order to improve the efficiency and results of your experiment, it is not suggested to try other species. Otherwise, it may lead to sample mismatch and affect the effect of your experiment.
2.Please aliquot the antibody received as soon as possible and store it at -20℃, avoid repeated freezing and thawing, and use it within one year.
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