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Claudin-1 Polyclonal Antibody

Claudin-1 Polyclonal Antibody

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Specification

Product name Claudin-1 Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human Claudin-1 at AA range: 140-220
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Molecular weight 22 KD
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Gene ID 9076
Alternative CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
Others Claudin-1 Polyclonal Antibody detects endogenous levels of Claudin-1 protein.
Accession O95832

Image & description

Fig. Western Blot analysis of various cells using Claudin-1 Polyclonal Antibody diluted at 1:1000.

Fig. Western Blot analysis of various cells using Claudin-1 Polyclonal Antibody diluted at 1:1000.

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