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CBP Polyclonal Antibody

CBP Polyclonal Antibody

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Specification

Product name CBP Polyclonal Antibody
Immunogen Synthesized peptide derived from human CBP around the non-acetylation site of K1535 at AA range: 1480-1550
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CREBBP; CBP; CREB-binding protein

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CREBBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), CREBBP is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREB binding protein has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREB binding protein acetylates both histone and non-histone proteins. CREB binding protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in CREBBP cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving CREBBP have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID 1387
Alternative CREBBP; CBP; CREB-binding protein
Others CBP Polyclonal Antibody detects endogenous levels of CBP protein.
Accession Q92793
Observed Band(KD) 265

Image & description

Fig.1. Western Blot analysis of various cells using CBP Polyclonal Antibody diluted at 1:1000.

Fig.1. Western Blot analysis of various cells using CBP Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of HT29 cells using CBP Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of HT29 cells using CBP Polyclonal Antibody diluted at 1:1000.

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