| Product name | Cathepsin B Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human Cathepsin B |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 38,40,25kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | CTSB encodes a member of the C1 family of peptidases. Alternative splicing of CTSB results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein (cathepsin B) has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of CTSB have been identified. |
| Gene ID | 1508 |
| Alternative | CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1 |
| Others | Cathepsin B Polyclonal Antibody detects endogenous levels of Cathepsin B protein. |
| Accession | P07858 |
| Observed Band(KD) | 38,40,25 |
Fig. Western Blot analysis of various cells using Cathepsin B Polyclonal Antibody.
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