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Caspase-6 (phospho Ser257) Polyclonal Antibody

Caspase-6 (phospho Ser257) Polyclonal Antibody

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Specification

Product name Caspase-6 (phospho Ser257) Polyclonal Antibody
Immunogen Synthesized peptide derived from human Caspase-6 around the phosphorylation site of S257
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CASP6 (caspase 6) encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.
Gene ID 839
Alternative CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2
Others Phospho-Caspase-6 (S257) Polyclonal Antibody detects endogenous levels of Caspase-6 protein only when phosphorylated at S257.
Accession P55212
Observed Band(KD) 15,30

Image & description

Fig. Western Blot analysis of Jurkat cells using Phospho-Caspase-6 (S257) Polyclonal Antibody diluted at 1:1000.

Fig. Western Blot analysis of Jurkat cells using Phospho-Caspase-6 (S257) Polyclonal Antibody diluted at 1:1000.

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