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Calpain 10 Polyclonal Antibody

Calpain 10 Polyclonal Antibody

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Specification

Product name Calpain 10 Polyclonal Antibody
Immunogen Synthesized peptide derived from the N-terminal region of human Calpain 10
Host Rabbit
Reactivity Human
Applications ELISA, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. CAPN10 encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. CAPN10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.
Gene ID 11132
Alternative CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10
Others Calpain 10 Polyclonal Antibody detects endogenous levels of Calpain 10 protein.
Accession Q9HC96
Observed Band(KD) 75

Image & description

Fig. Western Blot analysis of LOVO cells using Calpain 10 Polyclonal Antibody.

Fig. Western Blot analysis of LOVO cells using Calpain 10 Polyclonal Antibody.

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