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BMP-2 Polyclonal Antibody

BMP-2 Polyclonal Antibody

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Specification

Product name BMP-2 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human BMP-2
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background BMP2 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Gene ID 650
Alternative BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A
Others BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
Accession P12643
Observed Band(KD) 60

Image & description

Fig.1. Western Blot analysis of various cells using BMP-2 Polyclonal Antibody diluted at 1:500.

Fig.1. Western Blot analysis of various cells using BMP-2 Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of HuvEc cells using BMP-2 Polyclonal Antibody diluted at 1:500.

Fig.2. Western Blot analysis of HuvEc cells using BMP-2 Polyclonal Antibody diluted at 1:500.

Fig.3. Immunohistochemistry of paraffin-embedded human heart tissue using antibody at dilution 1:100.

Fig.3. Immunohistochemistry of paraffin-embedded human heart tissue using antibody at dilution 1:100.

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