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ATP-citrate synthase Polyclonal Antibody

ATP-citrate synthase Polyclonal Antibody

Views(46) Publications(0) Catalog no(ABP50733)
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Specification

Product name ATP-citrate synthase Polyclonal Antibody
Immunogen Synthesized peptide derived from human ATP-citrate synthase around the non-phosphorylation site of S455
Host Rabbit
Reactivity Human, Monkey, Mouse, Rat
Applications ELISA, IF, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for ACLY.
Gene ID 47
Alternative ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme
Others ATP-citrate synthase Polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein.
Accession P53396

Image & description

Fig.1. Western Blot analysis of various cells using ATP-citrate synthase Polyclonal Antibody diluted at 1:1000.

Fig.1. Western Blot analysis of various cells using ATP-citrate synthase Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of COS7 cells using ATP-citrate synthase Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of COS7 cells using ATP-citrate synthase Polyclonal Antibody diluted at 1:1000.

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