| Product name | Artn Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human Artn protein at amino acid sequence of 101-150 |
| Host | Rabbit |
| Reactivity | Human,Rat,Mouse, |
| Applications | IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200;ELISA 1:10000-20000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Artemin; Enovin; Neublastin |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | ARTN encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. |
| Gene ID | 9048 |
| Alternative | Artemin; Enovin; Neublastin |
| Others | The antibody detects endogenous levels of Artn |
| Accession | Q5T4W7 |
Fig.1. Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200.
Fig.2. Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200.
Fig.3. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
Fig.4. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
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