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Aldolase B Polyclonal Antibody

Aldolase B Polyclonal Antibody

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Specification

Product name Aldolase B Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human Aldolase B at AA range: 80-160
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ALDOB; ALDB; Fructose-bisphosphate aldolase B; Liver-type aldolase

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
Gene ID 229
Alternative ALDOB; ALDB; Fructose-bisphosphate aldolase B; Liver-type aldolase
Others Aldolase B Polyclonal Antibody detects endogenous levels of Aldolase B protein.
Accession P05062

Image & description

Fig.1. Western Blot analysis of various cells using Aldolase B Polyclonal Antibody.

Fig.1. Western Blot analysis of various cells using Aldolase B Polyclonal Antibody.

Fig.2. Western Blot analysis of HuvEc cells using Aldolase B Polyclonal Antibody.

Fig.2. Western Blot analysis of HuvEc cells using Aldolase B Polyclonal Antibody.

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