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ADCK1 Polyclonal Antibody

ADCK1 Polyclonal Antibody

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Specification

Product name ADCK1 Polyclonal Antibody
Immunogen Synthesized peptide derived from the Internal region of human ADCK1 at AA range: 220-300
Host Rabbit
Reactivity Human, Mouse
Applications ELISA, IF, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ADCK1; Uncharacterized aarF domain-containing protein kinase 1

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background CABC1 (chaperone activity of bc1 complex-like), also known as COQ8 or ADCK3 (aarF domain-containing protein kinase 3) is a 647 amino acid mitochondrial protein that belongs to the ADCK protein kinase. Ubiquitously expressed with higher expression in heart and skeletal muscle, CABC1 is thought to function as a chaperone in the proper assembly of protein complexes found in the respiratory chain. CABC1 expression is induced both in response to DNA damage and by the tumor suppressor p53. When CABC1 expression is inhibited, p53-induced apoptosis is partially suppressed, suggesting a possible role for CABC1 in tumor suppression. Mutations in the gene encoding CABC1 may be implicated in ubiquinone deficiency which can lead to cerebellar ataxia and seizures. Four isoforms of CABC1 exist due to alternative splicing events. Other members of the ADCK protein kinase family include ADCK1, ADCK2, ADCK4 and ADCK5.
Gene ID 57143
Alternative ADCK1; Uncharacterized aarF domain-containing protein kinase 1
Others ADCK1 Polyclonal Antibody detects endogenous levels of ADCK1 protein.
Accession Q86TW2

Image & description

Fig. Western Blot analysis of various cells using ADCK1 Polyclonal Antibody.

Fig. Western Blot analysis of various cells using ADCK1 Polyclonal Antibody.

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