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Acetyl Lysine Monoclonal Antibody

Acetyl Lysine Monoclonal Antibody

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Specification

Product name Acetyl Lysine Monoclonal Antibody
Immunogen Purified Protein
Host Mouse
Reactivity All
Applications IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000), IHC-P (1:200-1:500).
Clonality Monoclonal
Preparation method The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen
Alternative Lysine

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Acetylation of lysine, like phosphorylation of serine, threonine or tyrosine, is an important reversible modification controlling protein activity. The conserved amino-terminal domains of the four core histones (H2A, H2B, H3, and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs). Signaling resulting in acetylation/deacetylation of histones, transcription factors, and other proteins affects a diverse array of cellular processes including chromatin structure and gene activity, cell growth, differentiation, and apoptosis. Recent proteomic surveys suggest that acetylation of lysine residues may be a widespread and important form of posttranslational protein modification that affects thousands of proteins involved in control of cell cycle and metabolism, longevity, actin polymerization, and nuclear transport. The regulation of protein acetylation status is impaired in cancer and polyglutamine diseases , and HDACs have become promising targets for anti-cancer drugs currently in development.
Alternative Lysine
Others The antibody detects endogenous Acetyl Lysine protein.

Image & description

Fig.1. Western blot analysis of 1) Mouse Brain Tissue, 2) Hela, 3) Hela+TSA Treated using Acetyl Lysine Monoclonal Antibody.

Fig.1. Western blot analysis of 1) Mouse Brain Tissue, 2) Hela, 3) Hela+TSA Treated using Acetyl Lysine Monoclonal Antibody.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using Acetyl Lysine Monoclonal Antibody.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma using Acetyl Lysine Monoclonal Antibody.

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