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ABCB7 Polyclonal Antibody

ABCB7 Polyclonal Antibody

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Specification

Product name ABCB7 Polyclonal Antibody
Immunogen Synthesized peptide derived from the C-terminal region of human ABCB7 at AA range: 660-740
Host Rabbit
Reactivity Human
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative ABCB7; ABC7; ATP-binding cassette sub-family B member 7; mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The membrane-associated protein encoded by ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ATP binding cassette subfamily B member 7 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. ABCB7 encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in ABCB7 have been associated with mitochondrial iron accumulation and isodicentric (X) (q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for ABCB7.
Gene ID 22
Alternative ABCB7; ABC7; ATP-binding cassette sub-family B member 7; mitochondrial; ATP-binding cassette transporter 7; ABC transporter 7 protein
Others ABCB7 Polyclonal Antibody detects endogenous levels of ABCB7 protein.
Accession O75027

Image & description

Fig.1. Western Blot analysis of various cells using ABCB7 Polyclonal Antibody diluted at 1:1000.

Fig.1. Western Blot analysis of various cells using ABCB7 Polyclonal Antibody diluted at 1:1000.

Fig.2. Western Blot analysis of various cells using antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000.

Fig.2. Western Blot analysis of various cells using antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000.

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