Descriptions：CHI
Tags：CHI
Descriptions：Galectin-4 (Gal-4) is a lectin family member and is one of the tandem repeat-type galectins containing two carbohydrate recognition domains (CRD) connected by a linker region in a single peptide chain. The CRD is responsible for β-galactoside binding, and several binding partners for galectin-4 have been identified, including human blood group antigens, glycoproteins, mucin like membrane MUC1, glycosphingolipids, and sulfated cholesterol. Galectin-4 is constitutively presented in the intestine and stomach, uterine epithelial cells, blood vessel walls, hippocampal and cortical neurons. It serves important functions in numerous biological activities including lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, and host defense.
Tags：Galectin-4
Descriptions：Galectin-2 (Gal-2) is a lectin family member and structurally closely related to galectin-1. It contains one carbohydrate recognition domain (CRD), responsible for β-galactoside binding, and is biologically active as homodimers. Galectin-2 serves as a proapoptotic effector for activated T cells through caspase-3 signaling. Moreover, galectin-2 has emerged as a crucial factor in driving the macrophage to CD40-positive M1 polarization, leading to arteriogenesis attenuation and collateral arteries remodeling.
Applications：His tag
Tags：Galectin-2
Descriptions：Glial Cell Line-derived Neurotrophic Factor (GDNF) is the neurotrophic factor, belonging to the GDNF family of ligands (GFL) and identifying as a therapeutic candidate in Parkinson's disease.GDNF is a 23.7 kDa protein containing 211 residues that plays a critical role in promoting the survival and differentiation of midbrain dopamine neurons. Besides, GDNF is revealed to facilitate the development of peripheral tissues such as kidney, pancreas and lung. Additionally, as a member of GFL, GDNF also takes part in the progression of tumor.
Applications：His tag
Tags：GDNF
Descriptions：Fibroblast Growth Factors-6 (FGF-6) is a 22.9 kDa member of the fibroblast Growth Factors with 208 amino acid residues. FGF-6 is an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. In physiological function, FGF6 is required for normal muscle regeneration.
Applications：His tag
Tags：FGF-6
Descriptions：Bone Morphogenetic Protein-14 (BMP-14), known as Growth differentiation factor 5 (GDF5), is an extracellular multifunctional cytokine that is also a member of the TGFβ family. BMP-14 can bind with the TGFβ receptor and trigger SMAD protein signal transduction. BMP-14 plays a role in skeletal and joint development and increases the survival of neurons that respond to the neurotransmitter dopamine.
Applications：His tag
Tags：BMP-14
Descriptions：Galectin-10 (Gal-10) is a lectin family member and is one of the prototype galectins. It contains one carbohydrate recognition domain (CRD), responsible for β-galactoside binding, and is biologically active as homodimers. It has been reported that galectin-10 is presented in eosinophils but also detected in basophils and macrophages. Accumulated evidence indicates that galectin-10 spontaneously forms Charcot-Leyden crystals (CLCs), participating in allergic responses and related inflammatory reactions. Several binding partners for galectin-10 have been identified, including eosinophil granule cationic ribonucleases, eosinophil-derived neurotoxin (EDN, RNS2), and eosinophil cationic protein (ECP, RNS3), demonstrating the interaction is essential for eosinophil differentiation and granulogenesis.
Tags：Galectin-10
Descriptions：Calcium
Tags：Calcium
Descriptions：Interleukin 36 alpha (IL-36 alpha) is a 17.76 kDa cytokine with 160 amino acid residues. IL-36 alpha is an IL-1 family member, which binds to the Interleukin-1 receptor and is expressed in the lung, stomach, and placenta. IL-36 alpha is critical in inflammatory responses and stimulates the production of proinflammatory cytokines, such as IL-12, IL-1β, IL-6, and TNF-α. It also induces the generation of IFNγ, IL-4, and IL-17 in CD4+ T cells.
Applications：His tag
Tags：IL-36α
