Descriptions：发生形态蛋白4 (BMP-4)预测为13 kDa，是一种重要的调节分子，在人类发育过程中发挥重要作用，包括中胚层感应、牙齿生长、肢体、损伤和损伤修复，并在进行性化性纤维形成不良患者中过表达。BMP-4是因此早期和背腹轴建立所初始化的关键骨信号分子。由脊索背侧肩，并与音软骨细胞对接，骨背建立侧轴，为逆转结构的提供基础。
Tags：BMP-4
Descriptions：BAFF also known as BLYS, TALL-1 and TNFSF13B, which belongs to tumor necrosis factor family. BAFF is a 31.2 kDa type II transmembrane protein containing 285 residues that predominantly produced by myeloid cells, furthermore mouse BAFF shares 72% sequence identity with human BAFF. BAFF has been demonstrated to activate the survival of B cells and the B cell response by binding to BAFFR/BR3. Additionally, BAFF also takes part in regulating B and T cell function via forming two ligands-two receptors pathway through sharing TNFRSF13B/TACI and TNFRSF17/BCMA receptors with APRIL.
Tags：BAFF
Descriptions：AS
Tags：AS
Descriptions：Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is secreted by a number of different cell types (including activated T cells,Bcells,macrophages,mast cells,endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimulation.
Applications：His tag
Tags：M-CSF
Descriptions：CLL
Tags：CLL
Descriptions：Mouse IL-10 is the prototypic member of the IL-10 cytokine family,including IL-10,IL-19,IL-20,IL-22(IL-TIF),IL-24 and IL-26.
Applications：No tag
Tags：IL-10
Descriptions：Protein S100-A9, also known as S100 calcium binding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a calcium-binding protein. It has anti-microbial activity towards bacteria and fungi.
Tags：S100A9
Descriptions：SP
Tags：SP
Descriptions：GDF-3（以前称为Vgr-2）是TGF-β超家族成员，属于生长/分化因子家族。GDF-3在未分化的胚胎干细胞（ES细胞）、白色脂肪组织和脑中表达。小鼠GDF-3由366个氨基酸组成，包含一个22个氨基酸的信号序列、一个230个氨基酸的前肽和一个114个氨基酸的成熟蛋白，该成熟蛋白含有一个潜在的N-糖基化位点。成熟区包含一个在家族成员中保守的半胱氨酸结结构。然而，它缺少负责形成分子间二硫键的第四个半胱氨酸，因此GDF-3可能以非共价同型二聚体的形式存在。成熟的人GDF-3与小鼠和大鼠GDF-3的氨基酸序列同一性分别为83%和83%。大部分GDF-3以未裂解的前原形式存在。未分裂形式和成熟形式似乎均具有活性，但活性可能有所不同。所有形式均可对抗BMP。在ES细胞中，GDF-3抑制BMP2信号传导可维持多能性。GDF-3还影响早期细胞命运决定；例如，删除小鼠GDF-3会导致原肠胚形成前胚胎的前内脏内胚层出现缺陷。GDF-3在胚胎发生过程中与GDF-1协同作用，成熟蛋白具有类似节点的活性。虽然GDF家族成员通过BMP受体（ALK1、2、3和6）发出信号，从而激活Smads 1、5和8，但也有报道称GDF-3通过ALK4和ALK7发出信号，从而激活Smads 2和3。在脂肪细胞中，高脂饮食会诱导GDF-3，从而促进脂肪生成和肥胖。
Tags：GDF3
Descriptions：霍乱毒素 (CT) 是由霍乱弧菌产生的 AB5 型肠毒素，是霍乱症状的致病原因。一些文献表明，该毒素与糖蛋白结合，其 B 链与细胞表面的 GM1 神经节苷脂五糖结合。
Tags：Toxin B
