Descriptions:Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) is secreted by a number of different cell types (including activated T cells,Bcells,macrophages,mast cells,endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimulation.
Applications:His tag
Tags:M-CSF
Descriptions:白细胞介素-10 (IL-10),细胞因子合成抑制细胞因子(CSIF),是一种抗炎细胞因子。多种不同类型的产生IL-10,包括免疫细胞和非免疫细胞。IL-10树对突状细胞(DC)和巨噬细胞具有抑制作用,是呈递递的强效制剂,与Th1相关细胞因子IL-2和干扰素-γ(IFN-γ)的产生。IL-10也是感染期间的关键免疫调节剂,因为它能够抑制细胞因子的产生。因此,感染期间过度使用Th1和CD8+ T应答可能会受到抑制。
Tags:IL-10
Descriptions:Protein S100-A9, also known as S100 calcium binding protein A9, S100A9, and CAGB, is a member of the S-100 family. S100A9 is expressed by macrophages in acutely inflammed tissues and in chronic inflammation. It is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a calcium-binding protein. It has anti-microbial activity towards bacteria and fungi.
Tags:S100A9
Descriptions:AS
Tags:AS
Descriptions:CC基序趋化因子配体2 (CCL2) 是一个分子量为13.88 kDa的细胞因子,由125个氨基酸残基组成,又称单核细胞趋化蛋白1 (MCP1)。CCL2主要由单核细胞、巨噬细胞和树突状细胞分泌。它调节多种生物学功能,例如单核细胞、记忆T细胞、嗜酸性粒细胞和树突状细胞的募集,辅助性T细胞的外渗,对TNFα和IFNγ的应答,以及血管生成。此外,CCL2与CCR4结合后,可启动炎症反应中的白细胞迁移。
Tags:CCL2
Descriptions:BAFF also known as BLYS, TALL-1 and TNFSF13B, which belongs to tumor necrosis factor family. BAFF is a 31.2 kDa type II transmembrane protein containing 285 residues that predominantly produced by myeloid cells, furthermore mouse BAFF shares 72% sequence identity with human BAFF. BAFF has been demonstrated to activate the survival of B cells and the B cell response by binding to BAFFR/BR3. Additionally, BAFF also takes part in regulating B and T cell function via forming two ligands-two receptors pathway through sharing TNFRSF13B/TACI and TNFRSF17/BCMA receptors with APRIL.
Tags:BAFF
Descriptions:β-神经生长因子 (Beta-NGF) 是一种分子量为 27 kDa 的细胞因子,含有 241 个氨基酸残基。Beta-NGF 属于神经营养因子家族,具有神经营养因子的功能。它由 α、β、γ 亚基组成,其中 β 亚基与其生物活性相关。Beta-NGF 与 p75 神经营养因子受体和 Trk 受体结合,其功能分别与细胞死亡和存活相关。
Tags:β-NGF
Descriptions:宫殿状神经营养因子(CNTF)是IL-6细胞因子家族的成员,主要在神经系统中表达。CNTF与人类CNTF的序列同源性为84%。CNTF是一个分子量为22.9 kDa的神经营养因子,含有110个残基,在晚期发生中发挥多种作用。另外,CNTF作为一种启动子,不仅可以加速细胞发生,还可以提高损伤元后的坏死率。
Tags:CNTF
Descriptions:Fms相关酪氨酸肽3配体(Flt-3配体)是由小鼠Flt3lg基因编码的蛋白质。Flt-3配体作为造血的重要调节因子,酪氨酸肽3配体有活性,可刺激淋巴系和髓系造血祖细胞的增殖。Flt-3配体可配合使用他的细胞因子(如GM-CSF、G-CSF、IL-3、EPO、IL-11、IL-12、IL-6或TPO)很好地促进未成熟造血细胞的增殖。Flt-3配体在多种造血祖细胞中表达,包括未成熟造血细胞和骨髓基质细胞。
Tags:Flt-3 Ligand
Descriptions:表皮生长因子 (EGF) 是 EGF 蛋白家族的成员。EGF 主要由外胚层细胞、单核细胞、肾脏和十二指肠腺分泌。EGF 与其受体 EGFR 结合后,能够刺激上皮细胞生长和增殖,在许多发育过程中发挥重要作用,包括促进牙齿萌出、抑制胃酸分泌以及参与伤口愈合。
Tags:EGF