Descriptions:Fms相关酪氨酸蛋白酶3配体(Flt-3配体)是由人类FLT3LG基因编码的蛋白质。作为造血的重要调节因子,Flt-3配体酪氨酸蛋白酶具有活性,可刺激淋巴系和髓系造血祖细胞的增殖。Flt-3配体可与其他细胞因子(如GM-CSF、G-CSF、IL-3、EPO、IL-11、IL-12、IL-6或TPO)很好地促进未成熟造血祖细胞的增殖。Flt-3配体在多种造血祖细胞中表达,包括未成熟造血祖细胞和骨髓造血祖细胞。
Tags:Flt-3 Ligand
Descriptions:4-1BB ligand (4-1BBL) is a type II transmembrane protein that is part of the tumor necrosis factor (TNF) ligand family. As an inducible co-stimulatory molecule, it presents on several antigen presenting cell (APC) types, including B cells, macrophages and DCs. The interactions between 4-1BB and 4-1BBL trigger pleiotropic effects on the immune response including antigen presenting process, proliferation of CD4 and CD8 positive T-cells, as well as cytokine secretion from T-cells through NFκB, c-Jun, and p38 downstream signal pathways activation.Therefore, 4-1BB and 4-1BBL are recently used for the immunotherapy of cancer.
Applications:His tag
Tags:4-1BBL
Descriptions:Bone morphogenetic protein-2 (BMP-2) is a kind of bone growth regulator, belonging to protein transforming growth factor-β(TGF-β) superfamily. BMP-2 protein is involved in hedgehog pathway, TGF-β signaling pathway and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMP, which have been proved to be effective in inducing osteoblast differentiation in many cell types. The active form of BMP-2 can be composed of dimers of two identical proteins or heterodimers of two related bone morphogenetic proteins.
Tags:BMP-2
Descriptions:DHAR
Tags:DHAR
Descriptions:血管内皮生长因子165 (VEGF165)是一种强效的生长和血管生成细胞因子,属于VEGF家族,包括VEGF-A、VEGF-B、VEGF-C、VEGF-D、VEGF-E和PIGF。VEGF165是一种丰富的糖基化细胞因子,由缺少相同的165个血管链组成。VEGF165在血管生成、血管生成和神经发生中发挥重要作用。
Tags:VEGF165
Descriptions:NADP phosphatase (NADPase) is mainly present in plant tissues and is the only enzyme in organisms that catalyzes the degradation of NADP+ to NAD+. Together with NADK, it regulates the balance between NAD and NADP.
Descriptions:Interleukin-6(IL-6) is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine.It is secreted by T cells and macrophages to stimulate immune response.
Applications:No tag
Tags:IL-6
Descriptions:CC基序趋化因子配体4 (CCL4) 是一个分子量为7.66 kDa的细胞因子,含有69个氨基酸残基。CCL4,又称巨噬细胞炎症蛋白-1β (MIP-1β),主要由中性粒细胞、单核细胞、B细胞、T细胞、成纤维细胞、内皮细胞和上皮细胞分泌。当CCL4与CCR5结合时,它会募集各种免疫细胞,例如自然杀伤细胞、单核细胞和中性粒细胞。此外,CCL4还通过Rac1/Cdc42信号通路介导淋巴细胞粘附,并在维持细胞极性、调节钙离子转运和应对病毒等多种生物学功能中发挥关键作用。
Tags:CCL4
Descriptions:Ethanol
Tags:Ethanol
Descriptions:发生形态蛋白4 (BMP-4)预测为13 kDa,是一种重要的调节分子,在人类发育过程中发挥重要作用,包括中胚层感应、牙齿生长、肢体、损伤和损伤修复,并在进行性化性纤维形成不良患者中过表达。BMP-4是因此早期和背腹轴建立所初始化的关键骨信号分子。由脊索背侧肩,并与音软骨细胞对接,骨背建立侧轴,为逆转结构的提供基础。
Tags:BMP-4