| Product name | Synapsin I (phospho Ser9) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human Synapsin I around the phosphorylation site of S9 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | SYN1; Synapsin-1; Brain protein 4.1; Synapsin I |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 77kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | SYN1 is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded (synapsin I)serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of synapsin I in the nerve terminal. Mutations in SYN1 may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Gene ID | 6853 |
| Alternative | SYN1; Synapsin-1; Brain protein 4.1; Synapsin I |
| Others | Phospho-Synapsin I (S9) Polyclonal Antibody detects endogenous levels of Synapsin I protein only when phosphorylated at S9. |
| Accession | P17600 |
| Observed Band(KD) | 77 |
Fig.1. Western Blot analysis of various cells using Phospho-Synapsin I (S9) Polyclonal Antibody diluted at 1:1000.
Fig.2. Western Blot analysis of 3T3 cells using Phospho-Synapsin I (S9) Polyclonal Antibody diluted at 1:1000.
Fig.3. Western blot analysis of HELA KB 293T 3T3 lysis using Phospho-Synapsin I (S9) antibody. Antibody was diluted at 1:1000.
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