| Product name | SOCS7 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human SOCS7 protein |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Suppressor of cytokine signaling 7; SOCS-7; Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 63kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | SOCS7 (Suppressor Of Cytokine Signaling 7) is a Protein Coding gene. Among its related pathways are Jak-STAT signaling pathway (KEGG) and Prolactin Signaling Pathway. Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Gene ID | 30837 |
| Alternative | Suppressor of cytokine signaling 7; SOCS-7; Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4; NAP-4 |
| Others | The antibody detects endogenous levels of SOCS7 protein |
| Accession | O14512 |
| Observed Band(KD) | 63 |
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