| Product name | SMAP45 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the C-terminal region of human SMAP45 at AA range: 350-430 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat,Monkey |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 50kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 3 encoded by HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
| Gene ID | 8841 |
| Alternative | HDAC3; Histone deacetylase 3; HD3; RPD3-2; SMAP45 |
| Others | SMAP45 Polyclonal Antibody detects endogenous levels of SMAP45 protein. |
| Accession | O15379 |
| Observed Band(KD) | 50 |
Fig.1. Western Blot analysis of various cells using SMAP45 Polyclonal Antibody diluted at 1:2000.
Fig.2. Western Blot analysis of HepG2 cells using SMAP45 Polyclonal Antibody diluted at 1:2000.
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