| Product name | SKI-1 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the C-terminal region of human SKI-1 at AA range: 180-260 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,ELISA,IHC |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | MBTPS1; KIAA0091; S1P; SKI1; Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 130kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | MBTPS1 (membrane bound transcription factor peptidase, site 1) encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in MBTPS1 may be associated with lysosomal dysfunction. |
| Gene ID | 8720 |
| Alternative | MBTPS1; KIAA0091; S1P; SKI1; Membrane-bound transcription factor site-1 protease; Endopeptidase S1P; Subtilisin/kexin-isozyme 1; SKI-1 |
| Others | SKI-1 Polyclonal Antibody detects endogenous levels of SKI-1 protein. |
| Accession | Q14703 |
| Observed Band(KD) | 20 |
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