| Product name | Rb (phospho Ser780) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human Rb around the phosphorylation site of S780 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 106kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | RB transcriptional corepressor 1 encoded by RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. RB transcriptional corepressor 1 also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
| Gene ID | 5925 |
| Alternative | RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110 |
| Others | Phospho-Rb (S780) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S780. |
| Accession | P06400 |
Fig.1. Western Blot analysis of various cells using Phospho-Rb (S780) Polyclonal Antibody.
Fig.2. Western Blot analysis of KB cells using Phospho-Rb (S780) Polyclonal Antibody.
You must be logged in to post a review.
Reviews
There are no reviews yet.