| Product name | PTPRK Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human PTPRK protein at amino acid sequence of 180-260 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Receptor-type tyrosine-protein phosphatase kappa; Protein-tyrosine phosphatase kappa; R-PTP-kappa |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 158kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | The protein encoded by PTPRK is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRK possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. PTPRK was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of PTPRK was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. |
| Gene ID | 5796 |
| Alternative | Receptor-type tyrosine-protein phosphatase kappa; Protein-tyrosine phosphatase kappa; R-PTP-kappa |
| Others | The antibody detects endogenous levels of PTPRK protein |
| Accession | Q15262 |
| Observed Band(KD) | 158 |
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