| Product name | PRPF38A Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human PRPF38A at AA range: 80-160 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | PRPF38A; Pre-mRNA-splicing factor 38A |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 40kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | PRPF38A (Pre-mRNA-splicing factor 38A) is a 312 amino acid nuclear protein that is likely required for pre-mRNA splicing. There are two isoforms of PRPF38A that are produced as a result of alternative splicing events. The gene encoding PRPF38A maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. There are about 3000 genes on chromosome 1 and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. |
| Gene ID | 84950 |
| Alternative | PRPF38A; Pre-mRNA-splicing factor 38A |
| Others | PRPF38A Polyclonal Antibody detects endogenous levels of PRPF38A protein. |
| Accession | Q8NAV1 |
| Observed Band(KD) | 40 |
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