| Product name | OSM Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human OSM protein at amino acid sequence of 50-100 |
| Host | Rabbit |
| Reactivity | Human,Rat,Mouse, |
| Applications | IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200;ELISA 1:10000-20000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Oncostatin-M; OSM |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | OSM encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. OSM and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Gene ID | 5008 |
| Alternative | Oncostatin-M; OSM |
| Others | The antibody detects endogenous levels of OSM |
| Accession | P13725 |
Fig.1. Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200.
Fig.2. Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200.
Fig.3. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
Fig.4. Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
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