| Product name | Myosin VI Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Myosin VI at AA range: 40-120 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:5000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 149kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | MYO6 encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The unconventional myosin-VI consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Gene ID | 4646 |
| Alternative | MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6 |
| Others | Myosin VI Polyclonal Antibody detects endogenous levels of Myosin VI protein. |
| Accession | Q9UM54 |
| Observed Band(KD) | 149 |
Fig.1. Western Blot analysis of extracts from Jurkat cells, using Myosin VI Polyclonal Antibody. Secondary antibody (catalog#: A21020) was diluted at 1:20000.
Fig.2. Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100.
Fig.3. Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100.
Fig.4. Immunohistochemical analysis of paraffin-embedded rat-brain, antibody was diluted at 1:100.
Author：Goetzl EJ, Wolkowitz OM, Srihari VH, Reus VI, Goetzl L, Kapogiannis D, Heninger GR, Mellon SH Publication name：Mol Psychiatry IF：12.384
Author：Goetzl EJ, Srihari VH, Guloksuz S, Ferrara M, Tek C, Heninger GR Publication name：FASEB J IF：4.966
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