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Mouse RSPO1/R-spondin-1 Protein

Mouse RSPO1/R-spondin-1 Protein

Views(139) Publications(0) Catalog no(PRP1303)
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Specification

Product name Mouse RSPO1/R-spondin-1 Protein
Sequence Amino acid sequence derived from Mouse RSPO1 (Q9Z132) (Ser21-Gln265) was expressed.
Applications No tag
Applications notes Mouse
Activity Testing in progress
Protein length The recombinant Mouse RSPO1 Protein consists of 245 amino acids and predicts a molecular mass of 27.22 kDa.
Preparation method E.coli
Purity > 98 % as determined by SDS-PAGE
Molecular Formula 27.2 KDa
Alternative RSPO1, Roof plate-specific spondin-1

Product Properties

Formulation Lyophilized from sterile 20 mM Tris, 50 mM NaCl, pH8.0.
Features & Benefits < 0.1 EU per μg of the protein as determined by the LAL method.
Molecular weight 27.2 KDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
Gene ID 192199
Alternative RSPO1, Roof plate-specific spondin-1
Accession Q9Z132

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