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Mouse IL-7 Protein, His tag (Animal-Free)

Mouse IL-7 Protein, His tag (Animal-Free)

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Specification

Product name Mouse IL-7 Protein, His tag (Animal-Free)
Sequence Amino acid sequence derived from Mouse IL-7 (Met 26-Asn 154) (P10168) was expressed with 6×His tag and a Met at the C-terminus
Applications His tag
Applications notes Mouse
Activity Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBMC).The ED₅₀ for this effect is <0.2 ng/mL.The specific activity of recombinant mouse IL-7 is > 5 x 10⁶ IU/mg.
Protein length The recombinant Mouse IL-7 Protein consists of 129 amino acids and predicts a molecular mass of 15.8 kDa
Preparation method E. coli
Purity > 98% as determined by SDS-PAGE.
Alternative Lymphopoietin 1(LP-1), pre-B-cell factor, hlb368, A630026I06Rik

Product Properties

Formulation The protein was lyophilized from sterile PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.
Features & Benefits Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
Molecular weight 15.8 kDa
Usage notes Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously.
Storage instructions Lyophilized protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (5% HSA , 10%FBS or 0.1%BSA). Please prevent freeze-thaw cycles
Shipping The product is shipped with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Interleukin-7 (IL-7) is encoded by the IL7 gene in mouse and secreted by stromal cells in the red marrow and thymus. The protein signals through the IL-7 receptor, which is a heterodimer consisting of IL-7 receptor alpha and IL-2 receptor gamma chain. IL-7 stimulates the differentiation of hematopoietic stem cells into lymphoid progenitor cells and it can stimulate proliferation of B cells, T cells and NK cells. Murine IL-7 has approximately 65% and 88% amino acid sequence identity with human and rat IL-7 and both proteins exhibit cross-species activity. IL-7 as an immunotherapy agent has been examined in many human clinical trials for various malignancies and during HIV infection
Alternative Lymphopoietin 1(LP-1), pre-B-cell factor, hlb368, A630026I06Rik
Accession P10168

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