| Product name | Mouse IL-38 Protein, His tag (Animal-Free) |
| Sequence | Amino acid sequence derived from Mouse IL-38 (Met 1-Arg 152) (Q8R459) was expressed with 6×His tag at the C-terminus |
| Applications | His tag |
| Applications notes | Mouse |
| Activity | Testing in progress |
| Protein length | The recombinant Mouse IL-38 consists of 152 amino acids and predicts a molecular mass of 17.89 kDa |
| Preparation method | E. coli |
| Purity | >98% as determined by SDS-PAGE. |
| Alternative | interleukin 1 family, member 10, IL1F10 |
| Formulation | Lyophilized from PBS, pH 7.4 |
| Features & Benefits | Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method. |
| Molecular weight | 17.89 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously. |
| Storage instructions | Lyophilized protein product should be stored desiccated below -18°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (5% HSA , 10%FBS or 0.1%BSA). Please prevent freeze-thaw cycles |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | IL-38 (IL-1F10) mRNA is expressed in the heart, placenta, fetal liver, spleen, thymus, and tonsils. The expression of IL-1F10 in various immune tissues and its similarity with IL-1Ra indicate that IL-1F10 plays a role in inflammatory response. According to reports, removing interleukins from the IL-1F family, such as IL-1F5/6/8 or 9 (also known as IL-36Ra, IL-36) α、IL-36 β Or IL-36 γ). The n-terminal domain of is crucial for enhancing its biological activity. Recent studies have shown that IL-38 is processed and secreted by the N-terminus of apoptotic cells. The released processed IL-38 (20-152) and receptor interleukin-1 receptor associated protein like 1(IL1RAPL1;TIGIRR-2) are present on the surface of macrophages. Processed IL-38 activated IL-1RAPL1 reduces IL-6 production, leading to reduced inflammation |
| Alternative | interleukin 1 family, member 10, IL1F10 |
| Accession | Q8R459 |
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