| Product name | MLL4 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human MLL4 protein at amino acid sequence of 1060-1140 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | IHC,IF |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Histone-lysine N-methyltransferase 2B ; Lysine N-methyltransferase 2B; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 298kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | KMT2B (Lysine Methyltransferase 2B) is a Protein Coding gene. Diseases associated with KMT2B include Dystonia 28, Childhood-Onset and Spindle Cell Sarcoma. Among its related pathways are Chromatin organization and Lysine degradation. KMT2B encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. KMT2B is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for KMT2B, however, the full length nature of the shorter transcript is not known. |
| Gene ID | 9757 |
| Alternative | Histone-lysine N-methyltransferase 2B ; Lysine N-methyltransferase 2B; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7 |
| Others | The antibody detects endogenous levels of MLL4 protein |
| Accession | Q9UMN6 |
| Observed Band(KD) | 298 |
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