| Product name | MLH3 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human MLH3 at AA rangle: 490-570 |
| Host | Rabbit |
| Reactivity | Human |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 164kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. |
| Gene ID | 27030 |
| Alternative | MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3 |
| Others | MLH3 Polyclonal Antibody detects endogenous levels of MLH3 protein. |
| Accession | Q9UHC1 |
| Observed Band(KD) | 164 |
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