| Product name | LIGO1 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human LIGO1 protein at amino acid sequence of 370-450 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 68kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | LINGO1 (Leucine Rich Repeat And Ig Domain Containing 1) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling. GO annotations related to this gene include epidermal growth factor receptor binding. An important paralog of this gene is LINGO2. Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed: 14966521, PubMed: 15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed: 15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). |
| Gene ID | 84894 |
| Alternative | Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A |
| Others | The antibody detects endogenous levels of LIGO1 protein |
| Accession | Q96FE5 |
| Observed Band(KD) | 68 |
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