| Product name | LGMN Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human LGMN protein at amino acid sequence of 60-140 |
| Host | Rabbit |
| Reactivity | Human,Rat,Mouse |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Legumain; Asparaginyl endopeptidase; Protease; cysteine 1 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 47kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | LGMN encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of LGMN may be associated with the majority of solid tumor types. LGMN has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. |
| Gene ID | 5641 |
| Alternative | Legumain; Asparaginyl endopeptidase; Protease; cysteine 1 |
| Others | The antibody detects endogenous levels of LGMN protein |
| Accession | Q99538 |
| Observed Band(KD) | 47 |
Author：Q Feng, L Li, G Du Publication name：Research in Veterinary science IF：1.82
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