| Product name | Integrin β4 (phospho Tyr1510) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human Integrin β4 around the phosphorylation site of Y1510 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | ITGB4; Integrin beta-4; GP150; CD antigen CD104 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 202kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. ITGB4 encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Gene ID | 3691 |
| Alternative | ITGB4; Integrin beta-4; GP150; CD antigen CD104 |
| Others | Phospho-Integrin β4 (Y1510) Polyclonal Antibody detects endogenous levels of Integrin β4 protein only when phosphorylated at Y1510. |
| Accession | P16144 |
| Observed Band(KD) | 202 |
Fig. Western Blot analysis of AD293 using Phospho-Integrin β4 (Y1510) Polyclonal Antibody. Antibody was diluted at 1:500.
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