| Product name | Human OSM Protein |
| Sequence | Amino acid sequence derived from Human OSM (P13725) (Ala26-Arg252) was expressed. |
| Applications | No tag |
| Applications notes | Human |
| Activity | Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 0.4436 ng/mL. |
| Protein length | The recombinant Human OSM consists of 227 amino acids and predicts a molecular mass of 25.7 kDa. |
| Preparation method | E.coli |
| Purity | > 96 % as determined by SDS-PAGE |
| Molecular Formula | 25.7 kDa |
| Alternative | oncostatin-M |
| Formulation | Lyophilized from sterile 20mM Tris，150mM NaCl, pH 8.0. |
| Features & Benefits | Endotoxin : < 0.1 EU per μg of the protein as determined by the LAL method. |
| Molecular weight | 25.7 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously |
| Storage instructions | Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release(e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor). |
| Gene ID | 5008 |
| Alternative | oncostatin-M |
| Accession | P13725 |
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