| Product name | Human IL-12 p70 Protein, His tag (Animal-Free) |
| Sequence | Amino acid sequence derived from human IL-12p70, P29459(p35)(Arg23-Ser219), P29460(Ile23-Ser328) |
| Protein length | 63-75 kDa |
| Preparation method | E. coli |
| Purity | >98% as determined by SDS-PAGE. |
| Alternative | Interleukin-12, NKSF,Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF |
| Features & Benefits | Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method. |
| Molecular weight | 63-75 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Storage instructions | Please store the whole kit at -20°C upon receipt ,and protect from light. The kit is valid for 30 months. Please refer to the table below Materials supplied and Storage conditions to store all the components. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Interleukin 12 p70 (IL-12 p70) is an interleukin which is major secreted from immune cells like dendritic cells, macrophages and neutrophils. IL-12 p70 is a 58.5 kDa protein containing 527 amino acid residues which is composed by two subunits (IL-12 p35 and IL-12 p40). IL-12 p70 induces the cytotoxic activity of immune cells like NK cells and T cells. IL-12 p70 binds its receptor (IL-12Rβ1 and IL-12Rβ2) that activates the Jak/STAT signaling pathway. IL-12 p70 also plays an important role in cancer model which inhibits the formation of new blood vessels through the production of IFN γ. |
| Alternative | Interleukin-12, NKSF,Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF |
| Accession | P29459(p35), P29460( p40) |
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