| Product name | Human IL-11 Protein |
| Sequence | Amino acid sequence derived from IL11 Human (Pro22-Leu199)(P20809) was expressed. |
| Applications | No tag |
| Applications notes | Human |
| Activity | Measured by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is 1.982 ng/mL. |
| Protein length | The recombinant Human IL-11 consists of 178 amino acids and predicts a molecular mass of 19.14 KDa |
| Preparation method | E. coli |
| Purity | > 95 % as determined by SDS-PAGE |
| Alternative | IL11; AGIF; Adipogenesis Inhibitory Factor; Oprelvekin; IL-11; IL 11 |
| Formulation | Lyophilized from sterile 20 mM Tris with 150 mM NaCl, pH 7.4 |
| Features & Benefits | Endotoxin : <1.0 EUper μg of the protein as determined by the LAL method |
| Molecular weight | 19.14 kDa |
| Usage notes | Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized recombinant protein to a concentration of 0.1-1 mg/mL using the buffer we provided, and keep at room temperature for at least 20 min to fully dissolve. Please avoid vortex vigorously |
| Storage instructions | Lyophilized recombinant Human IL-11 Protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles |
| Shipping | The product is shipped at ambient temperature. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization |
| Gene ID | 3589 |
| Alternative | IL11; AGIF; Adipogenesis Inhibitory Factor; Oprelvekin; IL-11; IL 11 |
| Accession | P20809 |
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