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GRB10 Polyclonal Antibody

GRB10 Polyclonal Antibody

Views(2) Publications(0) Catalog no(ABP51473)
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Specification

Product name GRB10 Polyclonal Antibody
Immunogen Synthesized peptide derived from human GRB10 around the non-phosphorylation site of Y67
Host Rabbit
Reactivity Human,Rat,Mouse,
Applications WB,IHC,IF,ELISA
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Alternative GRB10; GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Molecular weight 67kD
Storage buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background Growth factor receptor-bound protein 10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. GRB10 encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. GRB10 is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID 2887
Alternative GRB10; GRBIR; KIAA0207; Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR
Others GRB10 Polyclonal Antibody detects endogenous levels of GRB10 protein.
Accession Q13322
Observed Band(KD) 67

Image & description

Fig.1. Western Blot analysis of various cells using GRB10 Polyclonal Antibody diluted at 1:2000.

Fig.1. Western Blot analysis of various cells using GRB10 Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of 3T3 cells using GRB10 Polyclonal Antibody diluted at 1:2000.

Fig.2. Western Blot analysis of 3T3 cells using GRB10 Polyclonal Antibody diluted at 1:2000.

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