| Product name | Endoglin Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human Endoglin protein at amino acid sequence of 370-430 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;IHC 1:500-200;ELISA 1:10000-20000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Endoglin; CD antigen CD105 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 70kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Endoglin encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in Endoglin cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Endoglin may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for Endoglin. |
| Gene ID | 2022 |
| Alternative | Endoglin; CD antigen CD105 |
| Others | The antibody detects endogenous levels of Endoglin |
| Accession | P17813 |
| Observed Band(KD) | 70 |
Fig.1. Western blot analysis of 3T3 KB K562 Hela 293T lysate, antibody was diluted at 1:500. HRP, Goat Anti-Rabbit IgG (Cat #: A21020) secondary antibody was diluted at 1:20000.
Fig.2. Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200.
Fig.3. Immunohistochemical analysis of paraffin-embedded human-tonsil, antibody was diluted at 1:200.
Fig.4. Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200.
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