| Product name | Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human Caspase-6 p18 at AA rangle: 90-170 |
| Host | Rabbit |
| Reactivity | Human,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 20kD,35kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms. |
| Gene ID | 839 |
| Alternative | CASP6; MCH2; Caspase-6; CASP-6; Apoptotic protease Mch-2 |
| Others | Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-6 p18 protein resulting from cleavage adjacent to D179. |
| Accession | P55212 |
| Observed Band(KD) | 20+35 |
Fig.1. Western Blot analysis of various cells using Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody diluted at 1:100O.
Fig.2. Western Blot analysis of 293 cells using Cleaved-Caspase-6 p18 (D179) Polyclonal Antibody diluted at 1:1000.
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