| Product name | Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Caspase-5 p10 at AA range: 290-370 |
| Host | Rabbit |
| Reactivity | Human, |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CASP5; ICH3; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 10kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | CASP5 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of caspase 5 induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by caspase 5; this process requires Fas-mediated dephosphorylation of Max. The expression of CASP5 is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for CASP5. |
| Gene ID | 838 |
| Alternative | CASP5; ICH3; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY |
| Others | Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-5 p10 protein resulting from cleavage adjacent to S331. |
| Accession | P51878 |
| Observed Band(KD) | 10 |
Fig. Western Blot analysis of various cells using Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody diluted at 1:1000.
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