| Product name | Claudin-6 (phospho Tyr219) Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from human Claudin-6 around the phosphorylation site of Y219 |
| Host | Rabbit |
| Reactivity | Human,Mouse |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CLDN6; Claudin-6; Skullin |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 23kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN6 (claudin 6) encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. CLDN6 methylation may be involved in esophageal tumorigenesis. CLDN6 is adjacent to another family member CLDN9 on chromosome 16. |
| Gene ID | 9074 |
| Alternative | CLDN6; Claudin-6; Skullin |
| Others | Phospho-Claudin-6 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-6 protein only when phosphorylated at Y219. |
| Accession | P56747 |
| Observed Band(KD) | 23 |
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