| Product name | ChemR23 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from the Internal region of human ChemR23 at AA range: 190-270 |
| Host | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IHC,IF,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000;IHC: 1:100-300;ELISA 1:20000;IF 1:100-300;Not yet tested in other applications. |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 42kD |
| Storage buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine b receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chem-otactic peptide receptor. It also acts as a coreceptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands. |
| Gene ID | 1240 |
| Alternative | CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
| Others | ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein. |
| Accession | Q99788 |
| Observed Band(KD) | 42 |
Fig.1. Western Blot analysis of various cells using ChemR23 Polyclonal Antibody diluted at 1:1000.
Fig.2. Western Blot analysis of COLO205 cells using ChemR23 Polyclonal Antibody diluted at 1:1000.
Fig.3. Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1000.
Fig.4. Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1000.
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