| Product name | AT2B2 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human AT2B2 protein at amino acid sequence of 250-330 |
| Host | Rabbit |
| Reactivity | Human,Rat |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Plasma membrane calcium-transporting ATPase 2; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 136kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | The protein encoded by ATP2B2 (ATPase Plasma Membrane Ca2+ Transporting 2) belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B2 encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Gene ID | 491 |
| Alternative | Plasma membrane calcium-transporting ATPase 2; PMCA2; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2 |
| Others | The antibody detects endogenous levels of AT2B2 protein |
| Accession | Q01814 |
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