| Product name | ARHG6 Polyclonal Antibody |
| Immunogen | Synthesized peptide derived from part region of human ARHG6 protein at amino acid sequence of 580-660 |
| Host | Rabbit |
| Reactivity | Human,Rat,Mouse |
| Applications | WB,ELISA |
| Applications notes | Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000;ELISA 1:5000-20000 |
| Clonality | Polyclonal |
| Preparation method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Alternative | Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Formulation | Liquid solution |
| Concentration | 1 mg/ml |
| Molecular weight | 85kD |
| Storage buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage instructions | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
| Shipping | Gel pack with blue ice. |
| Precautions | The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
| Background | ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Diseases associated with ARHGEF6 include X-Linked Non-Specific Intellectual Disability and Supraglottis Cancer. Among its related pathways are p75 NTR receptor-mediated signalling and Phospholipase-C Pathway. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in ARHGEF6 can cause X-chromosomal non-specific cognitive disability. |
| Gene ID | 9459 |
| Alternative | Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6 |
| Others | The antibody detects endogenous levels of ARHG6 protein |
| Accession | Q15052 |
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