Topic of This Issue: Magical Superoxide anion
Background: Superoxide ion (O2·−), which is considered both a radical and an anion with the radical sign ( . ) and a charge of −1, is produced by the one-electron reduction of molecular oxygen and is of great significance as a radical species implicated in diverse chemical and biological systems. Superoxide anion is a byproduct of respiration and a crucial component of the immune defense system. It can be generated from two major sources: the mitochondrial respiratory chain and phagocytic nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). Under normal circumstances, the biological system releases an enzyme, superoxide dismutase (SOD), which specifically maintains the Superoxide anion concentration at an optimal level. Nevertheless, whe n overproduction of Superoxide anion occurs and/or antioxidant…
Topic of This Issue: Mysterious Glutathione
Background: Glutathione plays an important role in antioxidant defense, nutrition metabolism and cell regulation (including gene expression, DNA and protein synthesis, cell proliferation and apoptosis, signal transduction, cytokine production and immune response, and protein glutathione). Glutathione deficiency leads to oxidative stress, which plays a key role in the pathogenesis of aging and many diseases (including malnutrition, epilepsy, Alzheimer's disease, Parkinson's disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, heart disease, stroke and diabetes). Product Recommendation: Product name Catalog No. Product Features CheKine™ Reduced Glutathione (GSH) Colorimetric Assay Kit KTB1600 • Determination of Reduced Glutathione concentration in serum, plasma, tissue/cell lysates and other biological fluids. • A broad…
New product | Focusing on glutathione metabolism- Abbkine new product coming in May!
It's time to release new products every month, so it's exciting to think about it! After the hard work of our R & D personnel, Abbkine welcomed 7 new partners in May! The new product line of this issue-glutathione series biochemical kits. The significance of glutathione research: Glutathione is a tripeptide containing glutamate, cysteine and glycine, which contains sulfhydryl groups. It is widely present in animals and plants. It has antioxidant and integrated detoxification effects. Its related coenzyme is NADPH. Too much free radicals produced by the body's metabolism can damage the biofilm, invade macromolecules of life, accelerate the body's aging, and induce the production of tumors or atherosclerosis. Glutathione has the functions of enhancing the antioxidant function of organisms,…
Hard work, Do not forget your initiative mind- Abbkine Added 210 Citations in April
In April 2020, Abbkine collected 210 English articles published using Abbkine products, and some of them sent us good news on their own initiative. The joy was beyond words. In this collection of articles, the highest impact factor (IF) is 13.05, with articles with IF>7 accounting for 10.4% and articles with IF>4 accounting for 43%. In the current evaluation of scientific research, scientific research papers, as the systematic summary and theoretical crystallization of scientific research carried out by scientific researchers, are still the main objects for measuring innovative activities, especially basic research activities. Science, Nature and Cell are internationally recognized journals with the highest academic reputation. According to the statistical results of Chinese scientific papers in 2018, the number of…
New product: IL-6, TNF-alpha, bFGF, IFN-gamma recombinant protein upgrading!
The new product line in this recombinant protein series: Human IL-6 protein：Interleukin 6 (IL-6) is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. IL-6 is an important member of the cytokine network and is central to the acute inflammatory response. After the production of IL-6, it induces the production of C-reactive protein (CRP) and procalcitonin (PCT), which are associated with inflammatory diseases and infections. The degree is directly related. IL-6 can quickly diagnose early inflammation and warn of sepsis. Human TNF-alpha protein：Tumor necrosis factor-α (TNF-α) is a cytokine involved in systemic inflammation, mainly secreted by macrophages. Its main function is to regulate immune cells. As an endogenous pyrogen, it can cause…
How to choose appropriate Catalase (CAT) Activity Assay Kit?
Catalase (CAT) is an antioxidant enzyme commonly found in almost all living organisms. Its main function is to catalyze the decomposition of hydrogen peroxide into water and oxygen and remove hydrogen peroxide in the body, thus preventing cells from being poisoned by H2O2. It is one of the key enzymes in the biological defense system and provides an antioxidant defense mechanism for the body. In this article, for CAT Activity Assay Kit, the author chose different brands (Cayman Chemical, Abcam, Biovision) and compared them with Abbkine CheKine™ Catalase (CAT) Activity Assay Kit (Cat#: KTB1040) from several aspects such as assay principle, detection, sample type and size/price. Summary: For CAT Activity Assay Kit, the brand Abbkine and Cayman Chemical are the similar in Assay Principle. Methanol…
How to choose appropriate NADP/NADPH Assay Kit?
NADP (coenzyme II) is the coenzyme of many redox reactions, including NADP+ (oxidation type) and NADPH (reduction type). NADP+ is also involved in biosynthesis reactions, such as lipid and nucleic acid synthesis. In animal cells, the oxidation stage of pentose phosphate pathway (PPP) is the main source of NADPH. In this article, for NADP/NADPH Assay Kit, the author chose different brands (BioAssay Systems, Abcam, Biovision) and compared them with Abbkine CheKine™NADP/NADPH Assay Kit (Cat#: KTB1010) from several aspects such as assay principle, detection, sample type and size/price. Summary: These brands are the similar in Assay Principle, Detection and Sample type. Prices are different. The price of Abbkine NADP/NADPH Assay Kit (Cat#: KTB1010) is the lowest. Besides good price, Abbkine NADP/NADPH Assay…
The Statement of Strengthening Epidemic Prevention for COVID-19
Dear Colleagues, The situation for COVID-19’s outbreak in Wuhan is getting improved in the strong supports of our government and caring people all over the world now. We are very lucky that we all are safe at present, while it’s still very important for us to do well protections. We determine to do below provisional measures during the resumption of production until the end of the outbreak in order to ensure the safe of all colleagues and our clients strictly. The establishment of epidemic prevention group, their works contain procurement of protection materials, temperature detection, virus kill, daily patrol and consults ect; Purchasing a batch of substance such as medicine alcohol, chlorine disinfectant, medical surgical masks, protective clothing, temperature guns…
How to Select an Antibody&Protein Coupling Kit with Super Cost Performance
1, The common definition of coupling technology Enzymes, biotin, fluorescent dye, agarose, magnetic beads and other substances which are easy to detect or separate are covalently labeled or conjugated to antibodies, proteins or other small molecular substances by a certain technology. 2, Background of Coupling Technology Coupling of antibodies, proteins or other small molecules is a necessary step in many types of biological experiments. For example, in order to detect specific proteins in immunoassays (such as WB/IHC/IF and other immunological experiments), we couple primary antibody or secondary antibody with enzyme, fluorescent dye, etc. In cell staining (biological imaging) applications, reactive dyes (fluorescent dye) are directly combined with extracellular or intracellular proteins (polypeptides) to produce visible and measurable staining. Coupling agarose…
Buy Abbkine selected primary antibodies, get high quality secondary antibodies
Abbkine's selected primary antibodies are the first choice for reliable trust, featuring a selection of popular research targets, strict quality control and quality assurance. We are grateful for everyone's recognition of this product line. In order to allow more customers to use good products and send out high-score articles, we are now launching the activity of buying selected primary antibodies and get high quality secondary antibodies. Promotion time: From now to December 31th, 2020 Details of activities: As long as you buy selected primary antibodies, you can get designated high quality secondary antibodies (size: 100ul) for free or at a very preferential price. Designated secondary antibodies are as follows, Product name Cat# Citation Size List Price($) Preferential Price($) HRP, Goat Anti-Mouse IgG…
