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VEGF Rabbit Polyclonal Antibody

VEGF Rabbit Polyclonal Antibody

Views(469) Publications(1) Catalog no(ABP57460)
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Specification

Product name VEGF Rabbit Polyclonal Antibody
Immunogen Recombinant Protein of VEGF of VEGFA
Host Rabbit
Reactivity Human, Mouse, Rat
Applications IHC-P
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative VEGFA

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background VEGFA (vascular endothelial growth factor A) is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of VEGFA in mice resulted in abnormal embryonic blood vessel formation. VEGFA is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of VEGFA have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Gene ID 7422
Alternative VEGFA
Others VEGF protein detects endogenous levels of VEGFA.
Accession P15692
Observed Band(KD) 23,45

Image & description

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Liver Carcinoma Tissue using VEGF Rabbit pAb diluted at 1:500.

Fig.1. Immunohistochemical analysis of paraffin-embedded Human Liver Carcinoma Tissue using VEGF Rabbit pAb diluted at 1:500.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using VEGF Rabbit pAb diluted at 1:500.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using VEGF Rabbit pAb diluted at 1:500.

Fig.3. Immunohistochemical analysis of paraffin-embedded Human Stomach Carcinoma Tissue using VEGF Rabbit pAb diluted at 1:500.

Fig.3. Immunohistochemical analysis of paraffin-embedded Human Stomach Carcinoma Tissue using VEGF Rabbit pAb diluted at 1:500.

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