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STAT2 Polyclonal Antibody

STAT2 Polyclonal Antibody

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Specification

Product name STAT2 Polyclonal Antibody
Immunogen Synthesized peptide derived from human Stat2 around the non-phosphorylation site of Y631
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC-P, WB
Applications notes Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.
Clonality Polyclonal
Preparation method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Alternative STAT2; Signal transducer and activator of transcription 2; p113

Product Properties

Formulation Liquid solution
Concentration 1 mg/ml
Storage buffer PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage instructions Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Gel pack with blue ice.
Precautions The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Additional Information

Background The protein encoded by STAT2 (signal transducer and activator of transcription 2) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for STAT2.
Gene ID 6773
Alternative STAT2; Signal transducer and activator of transcription 2; p113
Others Stat2 Polyclonal Antibody detects endogenous levels of Stat2 protein.
Accession P52630
Observed Band(KD) 98

Image & description

Fig.1. Western blot analysis of 1) K562,  2) Mouse Heart Tissue, 3) Rat Heart Tissue with STAT2 Rabbit pAb diluted at 1:2000.

Fig.1. Western blot analysis of 1) K562, 2) Mouse Heart Tissue, 3) Rat Heart Tissue with STAT2 Rabbit pAb diluted at 1:2000.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human SkinTissue using STAT2 Rabbit pAb diluted at 1:200.

Fig.2. Immunohistochemical analysis of paraffin-embedded Human SkinTissue using STAT2 Rabbit pAb diluted at 1:200.

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